HCV-IN-37

Names

[ CAS No. ]:
2425804-98-2

[ Name ]:
HCV-IN-37

Biological Activity

[Description]:

HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[Target]

EC50: 0.005 ± 0.005 μM (HCV)[1]


[References]

[1]. Wang Y, et al. Design, Synthesis, and Biological Evaluation of 2-((4-Bisarylmethyl-piperazin-1-yl)methyl)benzonitrile Derivatives as HCV Entry Inhibitors. J Med Chem. 2022 Feb 10;65(3):2107-2121.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H35F2N5

[ Molecular Weight ]:
515.64

Related Compounds