Pigment Red 3

Names

[ Name ]:
Pigment Red 3

[Synonym ]:
hansaredb
Toluidine Red
<2-Nitro-4-methyl-benzolazo>-naphthol-(2)
1-((4-Methyl-2-nitrophenyl)diazenyl)naphthalen-2-ol
EINECS 219-372-2
hansaredg
AKA221
PR 3
pigment red percent3
fastredr
1-(4-Methyl-2-nitro-phenylazo)-[2]naphthol
MFCD00003910
lakered4r
fastredje
HELIO FAST RED RL
fastredj
fastredab

Chemical & Physical Properties

[ Density]:
1.32 g/cm3

[ Boiling Point ]:
543.5ºC at 760 mmHg

[ Melting Point ]:
270-272 °C(lit.)

[ Molecular Formula ]:
C₁₇H₁₃N₃O₃

[ Molecular Weight ]:
307.30300

[ Exact Mass ]:
307.09600

[ PSA ]:
90.77000

[ LogP ]:
5.70060

[ Vapour Pressure ]:
8.02E-10mmHg at 25°C

[ Index of Refraction ]:
1.66

[ Stability ]:
Stable. May be moisture sensitive. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK4247000

CHEMICAL NAME :: 2-Naphthalenol, 1-((4-methyl-2-nitrophenyl)azo)-

CAS REGISTRY NUMBER :: 2425-85-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C17-H13-N3-O3

MOLECULAR WEIGHT :: 307.33

WISWESSER LINE NOTATION :: L66J BNUNR D1 BNW& CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/14D-C

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68 gm/kg/90D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 gm/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 273 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4368 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 3333 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,259,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,259,1993 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,259,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2109 No. of Facilities: 6944 (estimated) No. of Industries: 78 No. of Occupations: 56 No. of Employees: 47730 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2109 No. of Facilities: 4689 (estimated) No. of Industries: 57 No. of Occupations: 53 No. of Employees: 51931 (estimated) No. of Female Employees: 11615 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H410

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S26-S39-S60-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ RTECS ]:
QK4247000

[ HS Code ]:
2927000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2927000090

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

CI Pigment Red 3.

IARC Monogr. Eval. Carcinog. Risks Hum. 57 , 259-67, (1993)

14-day and 90-day toxicity studies of C.I. Pigment Red 3 in Fischer 344 rats and B6C3F1 mice.

Food Chem. Toxicol. 27(12) , 793-800, (1989)

Treatment of F344 rats and B6C3F1 mice with C.I. Pigment Red 3 in the diet (10, 5.0, 2.5, 1.25, 0.6 or 0.3%) for 14 and 90 days resulted in haematological alterations consistent with haemolytic anaemi...

Interlaboratory comparison of the toluidine red unheated serum test antigen preparation.

J. Clin. Microbiol. 20(3) , 434-7, (1984)

The toluidine red unheated serum test (TRUST) antigen, a macroscopic flocculation test antigen developed by Pettit et al. (J. Clin. Microbiol. 18:1141-1145, 1983) by modifying the color-coded antigen ...