HBV-IN-23

Names

[ CAS No. ]:
2413649-89-3

[ Name ]:
HBV-IN-23

Biological Activity

[Description]:

HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication with an IC50 of 0.58 µM. HBV-IN-23 inhibits HBV DNA replication in both drug sensitive and resistant HBV strains. HBV-IN-23 shows anti-hepatocellular carcinoma cell (HCC) activities. HBV-IN-23 induces HepG2 cells apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 0.58 µM (HBV DNA replication)[1]


[References]

[1]. Qiu J, et al. Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents. Eur J Med Chem. 2020 Nov 1;205:112581.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27N3O3S

[ Molecular Weight ]:
449.57

Related Compounds