Nile Blue chloride

Names

[ Name ]:
Nile Blue chloride

[Synonym ]:
NILE BLUE CHLORIDE
EINECS 219-181-4
Nile Blue BX
nilebluebase
cresolfastviolet
nile blue B
nileblueax
BASIC BLUE 12
Nile Blue A
5-amino-9-diethylamino-benzo[a]phenoxazin-5-ylium,chloride
MFCD00011936
NILE BLUE A CHLORIDE
c.i.basicblue12
5-amino-9-diethylamino-benzo[a]phenoxazinylium,chloride

Biological Activity

[Description]:

Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. QM Ali, et al. Z-scan determination of the third-order optical nonlinearity of organic dye nile blue chloride. Modern Physics Letters B. 2006, 623-632.

[2]. Martinez V, et al. Nile Red and Nile Blue: Applications and Syntheses of Structural Analogues. Chemistry. 2016 Sep 19;22(39):13764-13782.

Chemical & Physical Properties

[ Boiling Point ]:
487.9ºC at 760mmHg

[ Melting Point ]:
>250°C

[ Molecular Formula ]:
C₂₀H₂₀ClN₃O

[ Molecular Weight ]:
353.84500

[ Flash Point ]:
248.8ºC

[ Exact Mass ]:
353.12900

[ PSA ]:
55.06000

[ LogP ]:
1.06520

[ Water Solubility ]:
Solubility Soluble in water, ethanol

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ1930000

CHEMICAL NAME :: Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride

CAS REGISTRY NUMBER :: 2381-85-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H20-N3-O.Cl

MOLECULAR WEIGHT :: 353.88

WISWESSER LINE NOTATION :: T D6 B666 CN JOJ GN2&2 MZ &G &15/28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 1 ppm

REFERENCE :: POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920- Volume(issue)/page/year: 34,114,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4350 No. of Facilities: 71 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3549 (estimated) No. of Female Employees: 1329 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ RTECS ]:
DJ1930000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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