NH4-6

Names

[ Name ]:
NH4-6

Biological Activity

[Description]:

NH4-6 is a potent, selective pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively.NH4-6 does not inhibits SIRT5 and SIRT6.NH4-6 (30 mg/kg) significantly impaired tumor growth in HCT-116 tumor xenograft.

[References]

1. Jun Young Hong, et al. ACS Chem Biol. 2021 Jul 16;16(7):1266-1275.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₅₉In₄O₃S

[ Molecular Weight ]:
718.824

Related Compounds

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