Licarin A

Names

[ Name ]:
Licarin A

[Synonym ]:
Isoeugenol,dehydrodi
2-Methoxy-4-{(2S,3S)-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2,3-dihydro-1-benzofuran-2-yl}phenol
DEHRODIISOEUGENOL
Phenol, 4-[(2S,3S)-2,3-dihydro-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2-benzofuranyl]-2-methoxy-
Diisoeugenol,dehydro
Licarin A
dehydrodiisoeugenol

Biological Activity

[Description]:

(±)-Licarin A ((±)-trans-Dehydrodiisoeugenol) is a dihydrobenzofuran neolignan, the resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. (±)-Licarin A displays 58.7% parasite lysis and has an IC50 value of 100.8 µM for trypanocidal activity against trypomastigote forms of T. cruzi. And (±)-Licarin A shows 100% parasites mortality at 200 µM[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Meleti VR, et al. (±)-licarin A and its semi-synthetic derivatives: in vitro and in silico evaluation of trypanocidaland schistosomicidal activities. Acta Trop. 2019 Oct 29:105248.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
452.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₄

[ Molecular Weight ]:
326.386

[ Flash Point ]:
227.2±28.7 °C

[ Exact Mass ]:
326.151794

[ PSA ]:
47.92000

[ LogP ]:
4.19

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.596

Related Compounds

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