Swertianolin

Names

[ Name ]:
Swertianolin

[Synonym ]:
5,8-Dihydroxy-3-methoxy-9-oxo-9H-xanthen-1-yl β-D-glucopyranoside
Sw-bromoacetophenone semicarbazone
2-bromo-1-phenyl-ethanone semicarbazone
bellidifolin 8-O-glucopyranoside
9H-Xanthen-9-one, 1-(β-D-glucopyranosyloxy)-5,8-dihydroxy-3-methoxy-
2-Brom-1-phenyl-aethanon-semicarbazon
SWERTIANOLIN
phenacyl bromide semicarbazone

Biological Activity

[Description]:

Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> AChE

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Urbain A, et al. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4.

[2]. Xiu-Qiao Zhang, et al. Anti-HBV Activities of Xanthones From Swertia Punicea Hemsl. N A J Med Sci. 2014;7(2):72-74.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
806.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₁₁

[ Molecular Weight ]:
436.366

[ Flash Point ]:
287.7±27.8 °C

[ Exact Mass ]:
436.100555

[ PSA ]:
179.28000

[ LogP ]:
-1.13

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZD6057000

CHEMICAL NAME :: Xanthen-9-one, 5,8-dihydroxy-1-(beta-D-glucopyranosyloxy)-3-methoxy-

CAS REGISTRY NUMBER :: 23445-00-3

LAST UPDATED :: 199503

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H20-O11

MOLECULAR WEIGHT :: 436.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985