GW9662
Names
[ CAS No. ]:
22978-25-2
[ Name ]:
GW9662
[Synonym ]:
MFCD01215270
Benzamide, 2-chloro-5-nitro-N-phenyl-
2-Chloro-5-nitro-N-phenylbenzamide
GW-9662
GW9662
Biological Activity
[Description]:
[Related Catalog]:
[Target]
PPARγ:3.3 nM (IC50)
PPARα:32 nM (IC50)
PPARδ:2000 nM (IC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
360.9±32.0 °C at 760 mmHg
[ Melting Point ]:
171-175 °C(lit.)
[ Molecular Formula ]:
C13H9ClN2O3
[ Molecular Weight ]:
276.675
[ Flash Point ]:
172.0±25.1 °C
[ Exact Mass ]:
276.030182
[ PSA ]:
74.92000
[ LogP ]:
2.76
[ Appearance of Characters ]:
solid | white
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.676
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: 26 mg/mL, soluble
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H317-H319
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36;R43
[ Safety Phrases ]:
S26-S36/37-S24/25-S22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2924299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Preparation
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Neurobiol. Dis. 74 , 295-304, (2015)
Long-term administration of l-3,4-dihydroxyphenylalanine (levodopa), the mainstay treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of action and motor complicatio...
Telmisartan attenuated LPS-induced neuroinflammation in human IMR-32 neuronal cell line via SARM in AT1R independent mechanism.Life Sci. 130 , 88-96, (2015)
The aim of this study was to find the protective role of Telmisartan (TS) in LPS intoxicated neuronal cells and elucidate the possible neuroprotective mechanism of action.TLR4 and AT1R specific primer...
Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-γ function.J. Neurosci. Res. 92(11) , 1549-59, (2014)
The turmeric derivative curcumin protects against cerebral ischemic injury. We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated ...