Curcumin β-D-Glucuronide

Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer[1][2].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Curcumin-β-D-glucuronide (90 mg/kg; i.p. thrice a week for 3 weeks) exhibit potent anti-tumor effects on KRASm/TP53w HCT116 xenograft model[1]. Animal Model: Female BALB/c/AnNCr j‐nu/nude mice (6 weeks) were transplanted KRASm/TP53w HCT116 cells[1] Dosage: 90 mg/kg Administration: I.p. thrice a week for 3 weeks Result: Suppressed tumor growth by 38%. Did not show a negative impact on body weight. Attenuated NF‐κB activity.

[1]. Ozawa-Umeta H, et, al. Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer Sci. 2020 May;111(5):1785-1793.

[2]. Ozawa H, et, al. Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biol Pharm Bull. 2017;40(9):1515-1524.