Tauro-α-muricholic acid sodium

Names

[ CAS No. ]:
2260905-08-4

[ Name ]:
Tauro-α-muricholic acid sodium

[Synonym ]:
Sodium 2-{[(3α,5β,6β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
Ethanesulfonic acid, 2-[[(3α,5β,6β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)

Biological Activity

[Description]:

Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR
Research Areas >> Others

[Target]

Microbial Metabolite


[References]

[1]. Chen W, et al. Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect. Int J Med Sci. 2023 Apr 2;20(5):595-605.  

[2]. Ye X, et al. Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism. Eur J Pharmacol. 2021 Oct 5;908:174341.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H44NNaO7S

[ Molecular Weight ]:
537.68

[ Exact Mass ]:
537.273621

[ Appearance of Characters ]:
A crystalline solid

[ Storage condition ]:
-20°C

[ Water Solubility ]:
DMF: 10 mg/mL ; DMSO: 10 mg/mL ; Ethanol: 1 mg/mL