Gymnemagenin

Names

[ Name ]:
Gymnemagenin

[Synonym ]:
Protoaescigenin
Olean-12-ene-3,16,21,22,23,28-hexol, (3β,16β,21β,22α)-
(3β,16β,21β,22α)-Olean-12-ene-3,16,21,22,23,28-hexol
Gymnemagenin

Biological Activity

[Description]:

Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Gymnemagenin has a poor oral bioavailability (~ 14 %) in rats[2]. Gymnemagenin has a short half-life and a high clearance in rats[2]. Gymnemagenin metabolizes rapidly with a short apparent and intrinsic half-life (~ 7 min) and high intrinsic clearance[2].

[References]

[1]. Parthasarathy R, et al. Gymnemagenin-producing endophytic fungus isolated from a medicinal plant Gymnema sylvestre R.Br. Appl Biochem Biotechnol. 2014 Mar;172(6):3141-52.

[2]. In Vitro Metabolic Stability and Permeability of Gymnemagenin and Its In Vivo Pharmacokinetic Correlation in Rats - A Pilot Study.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
634.5±55.0 °C at 760 mmHg

[ Melting Point ]:
330-331℃

[ Molecular Formula ]:
C₃₀H₅₀O₆

[ Molecular Weight ]:
506.714

[ Flash Point ]:
262.0±26.1 °C

[ Exact Mass ]:
506.360748

[ PSA ]:
121.38000

[ LogP ]:
3.98

[ Vapour Pressure ]:
0.0±4.2 mmHg at 25°C

[ Index of Refraction ]:
1.598

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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