9-Hydroxy-alpha-lapachone

Names

[ Name ]:
9-Hydroxy-alpha-lapachone

[Synonym ]:
9-Hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-9-hydroxy-2,2-dimethyl-

Biological Activity

[Description]:

9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC50 of 4.64 µM on LPS-induced NO production in RAW 264.7 cells[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. Byeong Min Park, et al. Naphthoquinones from Catalpa ovata and their inhibitory effects on the production of nitric oxide. Arch Pharm Res. 2010 Mar;33(3):381-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
436.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₄O₄

[ Molecular Weight ]:
258.27

[ Flash Point ]:
166.4±22.2 °C

[ Exact Mass ]:
258.089203

[ PSA ]:
63.60000

[ LogP ]:
3.19

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.624

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914400090

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%