Noladin ether

Names

[ Name ]:
Noladin ether

[Synonym ]:
2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol
2-AG ether
2-Arachidonyl Glycerol ether
2-arachidonyl glyceryl ether
1,3-Propanediol, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yloxy]-
2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraen-1-yloxy]-1,3-propanediol
2-[(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraen-1-yloxy]propane-1,3-diol
2-AG ether HU 310
Noladin
noladin ether
1,3-Propanediol, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyloxy]-

Biological Activity

[Description]:

Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1:21.2 nM (Ki)

CB2:>3 mM (Ki)

[References]

[1]. Hanus L, et, al. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
488.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₄₀O₃

[ Molecular Weight ]:
364.562

[ Flash Point ]:
249.5±28.7 °C

[ Exact Mass ]:
364.297760

[ PSA ]:
49.69000

[ LogP ]:
6.69

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.503

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ RIDADR ]:
UN1170 - class 3 - PG 2 - Ethanol, solution

Related Compounds

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