Patritumab deruxtecan
Names
[ CAS No. ]:
2227102-46-5
[ Name ]:
Patritumab deruxtecan
Biological Activity
[Description]:
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity[1].
[Related Catalog]:
[In Vitro]
Patritumab deruxtecan 对表达 HER3 突变的乳腺癌细胞表现出活性,无论HER2是否过表达[1]。 Patritumab deruxtecan (0-100 nM) 以浓度依赖性方式结合所有 HER3 突变体和 HER3WT MDA-MB-231 细胞的表面,但不结合 HER3< sup>EV 细胞[1].
[References]
Chemical & Physical Properties
No Any Chemical & Physical Properties