Lyn peptide inhibitor TFA

Names

[ CAS No. ]:
222018-18-0

[ Name ]:
Lyn peptide inhibitor TFA

[Synonym ]:
L-Prolinamide, N-(1-oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-
N-Stearoyl-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolinamide

Biological Activity

[Description]:

Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Research Areas >> Inflammation/Immunology

[Target]

IC50: Lyn kinase[1]

[References]

[1]. T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501.

[2]. T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163(2):939-46.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₁₅H₁₈₄N₃₀O₂₄

[ Molecular Weight ]:
2370.878

[ Exact Mass ]:
2369.409912

[ LogP ]:
4.55

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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