(Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH acetate salt

Names

[ CAS No. ]:
220810-26-4

[ Name ]:
(Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH acetate salt

Biological Activity

[Description]:

Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis[1][2][5].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Cancer

[References]

[1]. Emma D Deeks, et al. Histrelin: in advanced prostate cancer. Drugs. 2010 Mar 26;70(5):623-30.

[2]. Marlena Juszczak, et al. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res Bull. 2010 Jan 15;81(1):185-90.

[3]. P E Cohen, et al. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Mol Endocrinol. 1997 Oct;11(11):1636-50.

[4]. D W Hahn, et al. Development of an animal model for quantitatively evaluating effects of drugs on endometriosis. Fertil Steril. 1985 Sep;44(3):410-5.

[5]. E Boczek-Leszczyk, et al. Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone (GnRH), its analogues and melatonin. J Physiol Pharmacol. 2010 Aug;61(4):459-66.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₆H₈₆N₁₈O_12.xC₂H₄O₂

[ Molecular Weight ]:
1323.50 (free base)

[ Exact Mass ]:
1442.71000

[ PSA ]:
521.46000

[ LogP ]:
3.97960