IMM-02

Names

[ Name ]:
IMM-02

[Synonym ]:
Hydrazinecarbothioamide, 2-[1-(3,5-difluoro-2-hydroxyphenyl)ethylidene]-1-(1,1-dimethylethyl)-, (2E)-
(2E)-2-[1-(3,5-Difluoro-2-hydroxyphenyl)ethylidene]-1-(2-methyl-2-propanyl)hydrazinecarbothioamide

Biological Activity

[Description]:

IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM; sufficiently triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis in vitro; slows tumor growth in a mouse xenograft model of colon cancer.

[References]

References 1. Lash LL, et al. Cancer Res. 2013 Nov 15;73(22):6793-803. 2. Arden JD, et al. Mol Biol Cell. 2015 Nov 1;26(21):3704-18. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
390.4±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₇F₂N₃OS

[ Molecular Weight ]:
301.355

[ Flash Point ]:
189.9±30.7 °C

[ Exact Mass ]:
301.106049

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.552

Related Compounds

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