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Euphorbia factor L2

Names

[ CAS No. ]:
218916-51-9

[ Name ]:
Euphorbia factor L2

[Synonym ]:
4H-Cyclopenta[a]cyclopropa[f]cycloundecen-4-one, 4a,8-bis(acetyloxy)-7,11-bis(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-, (1aR,2E,4aR,6S,7S,7aR,8R,11S,11aS)-
(1aR,2E,4aR,6S,7S,7aR,8R,11S,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-9-methylene-4-oxo-1a,4,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1H-cyclopenta[a]cyclopropa[f][11]annulene-7,11-diyl dibenzoate
MFCD11111355

Biological Activity

[Description]:

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Lin M, et al. Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway. Acta Pharm Sin B. 2017 Jan;7(1):59-64.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
697.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H42O9

[ Molecular Weight ]:
642.735

[ Flash Point ]:
284.6±31.5 °C

[ Exact Mass ]:
642.282898

[ LogP ]:
8.36

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds