Dihydrorhodamine 6G

Names

[ Name ]:
Dihydrorhodamine 6G

[Synonym ]:
Benzoic acid, 2-[3,6-bis(ethylamino)-2,7-dimethyl-9H-xanthen-9-yl]-, ethyl ester
Ethyl 2-[3,6-bis(ethylamino)-2,7-dimethyl-9H-xanthen-9-yl]benzoate

Biological Activity

[Description]:

Dihydrorhodamine 6G (DHR 6G) is the reduced form of Rhodamine 6G, which is used as fluorescent mitochondrial dye. It is nonfluorescent, but it readily enters most of the cells and is oxidized by oxidative species or by cellular redox systems to the fluorescent rhodamine 6G that accumulates in mitochondrial membranes. Dihydrorhodamine 6G is useful for detecting reactive oxygen species (ROS) including superoxide[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Yong Qin, et al. Dihydrorhodamine 123 is superior to 2,7-dichlorodihydrofluorescein diacetate and dihydrorhodamine 6G in detecting intracellular hydrogen peroxide in tumor cells. Cell Biol Int. 2008 Feb;32(2):224-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
572.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₂N₂O₃

[ Molecular Weight ]:
444.565

[ Flash Point ]:
300.0±30.1 °C

[ Exact Mass ]:
444.241302

[ LogP ]:
6.95

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.625