BAY-155
Names
[ CAS No. ]:
2163769-52-4
[ Name ]:
BAY-155
Biological Activity
[Description]:
BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503;BAY-155 demonstrated a significantly enhanced selectivity profile compared to MI-503 in a panel of assays covering numerous safety pharmacology-relevant targets including GPCRs, ion channels and transporters.BAY-155 shows anti-proliferative activity in a large cell line panel, exhibits specific therapeutic activityin AML/ALL models.
[References]
1. Krzysztof Brzezinka, et al. Cancers (Basel). 2020 Jan 14;12(1):201.
Chemical & Physical Properties
[ Molecular Formula ]:
C28H28F3N7Os
[ Molecular Weight ]:
567.635
Related Compounds
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