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ONO-8711

Names

[ CAS No. ]:
216158-34-8

[ Name ]:
ONO-8711

[Synonym ]:
(5Z)-6-[(2R,3S)-3-({[(4-Chloro-2-methylphenyl)sulfonyl]amino}methyl)bicyclo[2.2.2]oct-2-yl]-5-hexenoic acid
5-Hexenoic acid, 6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-, (5Z)-

Biological Activity

[Description]:

ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Watanabe K, et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res. 1999 Oct 15;59(20):5093-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
605.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H30ClNO4S

[ Molecular Weight ]:
439.996

[ Flash Point ]:
319.8±34.3 °C

[ Exact Mass ]:
439.158417

[ PSA ]:
91.85000

[ LogP ]:
6.01

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds