(S,R,S)-AHPC-PEG3-propionic acid

Names

[ CAS No. ]:
2140807-42-5

[ Name ]:
(S,R,S)-AHPC-PEG3-propionic acid

Biological Activity

[Description]:

(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL


[References]

[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H46N4O9S

[ Molecular Weight ]:
662.79

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds