7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

Names

[ Name ]:
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

[Synonym ]:
8-Aza-guanosin
9-ss-D-ribofuranosyl-8-aza-guanin
Azaguanosine
8-aza-guanosine

Biological Activity

[Description]:

8-Azaguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.49g/cm3

[ Boiling Point ]:
567.3ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₂N₆O₅

[ Molecular Weight ]:
284.23

[ Flash Point ]:
296.9ºC

[ Exact Mass ]:
284.08700

[ PSA ]:
172.40000

[ Vapour Pressure ]:
3.13E-15mmHg at 25°C

[ Index of Refraction ]:
2.059

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ6157200

CHEMICAL NAME :: 7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-3,6-dihydro-3-beta-D-ribofuranosyl

CAS REGISTRY NUMBER :: 2133-80-4

BEILSTEIN REFERENCE NO. :: 0046037

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H12-N6-O5

MOLECULAR WEIGHT :: 284.27

WISWESSER LINE NOTATION :: T56 BNNN FVM INJ HZ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970