<Suppliers Price>

Mal-(CH2)5-Val-Cit-PAB-Eribulin

Names

[ CAS No. ]:
2130869-21-3

[ Name ]:
Mal-(CH2)5-Val-Cit-PAB-Eribulin

Biological Activity

[Description]:

Mal-(CH2)5-Val-Cit-PAB-Eribulin is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-microtubule agent, Eribulin, linked via linker Mal-(CH2)5-Val-Cit-PAB[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules[2].

[References]

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. Patent US20170252458A1.

[2]. Watanabe K, et, al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4; 10(2): 161-174.

Chemical & Physical Properties

[ Molecular Formula ]:
C69H97N7O19

[ Molecular Weight ]:
1328.54

Related Compounds