Triadimenol-d4

Triadimenol-d4 is the deuterium labeled Triadimenol[1]. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals[2].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Menegola E, et al. In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol. In Vitro Cell Dev Biol Anim. 2000 Feb;36(2):88-95.