C5-benzyl SAHA
Names
[ CAS No. ]:
2115700-64-4
[ Name ]:
C5-benzyl SAHA
Biological Activity
[Description]:
C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM); dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.
[References]
References 1. Negmeldin AT, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258. View Related Products by Target HDAC
Chemical & Physical Properties
[ Molecular Formula ]:
C21H26N2O3
[ Molecular Weight ]:
354.45