Dihomo-γ-Linolenic acid methyl ester

Names

[ Name ]:
Dihomo-γ-Linolenic acid methyl ester

[Synonym ]:
Methyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
8,11,14-Eicosatrienoic acid, methyl ester, (8Z,11Z,14Z)-
Methyl (8Z,11Z,14Z)-8,11,14-icosatrienoate
methyl icosa-8,11,14-trienoate
8,11,14-Eicosatrienoic acid, methyl ester, (Z,Z,Z)-

Biological Activity

[Description]:

Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Takai S, et al. Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice. J Atheroscler Thromb. 2009;16(4):480-489.

[2]. Chutrakul C, et al. Metabolic engineering of long chain-polyunsaturated fatty acid biosynthetic pathway in oleaginous fungus for dihomo-gamma linolenic acid production. J Biotechnol. 2016;218:85-93.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
405.0±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₆O₂

[ Molecular Weight ]:
320.509

[ Flash Point ]:
99.6±21.2 °C

[ Exact Mass ]:
320.271515

[ PSA ]:
26.30000

[ LogP ]:
8.02

[ Appearance of Characters ]:
Liquid

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
UN1170 - class 3 - PG 2 - Ethanol, solution

[ WGK Germany ]:
3

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%