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Fmoc-NH-PEG10-acid

Names

[ CAS No. ]:
2101563-45-3

[ Name ]:
Fmoc-NH-PEG10-acid

[Synonym ]:
Fmoc-NH-PEG10-CH2CH2COOH
MFCD28122954
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34-undecaoxa-4-azaheptatriacontan-37-oic acid
2,7,10,13,16,19,22,25,28,31,34-Undecaoxa-4-azaheptatriacontan-37-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-

Biological Activity

[Description]:

Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
826.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H57NO14

[ Molecular Weight ]:
751.857

[ Flash Point ]:
453.6±34.3 °C

[ Exact Mass ]:
751.377930

[ LogP ]:
0.15

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.522

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds