Ermanin

Names

[ CAS No. ]:
20869-95-8

[ Name ]:
Ermanin

[Synonym ]:
5,7-Dihydroxy-3,4'-dimethoxyflavone
5,7-Dihydroxy-3-methoxy-2-(4-methoxy-; phenyl)-chromen-4-one
5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
3,4'-Dimethoxychrysin
Kaempferol 3,4'-di-O-methyl ether
Ermanin
3',5,7-trihydroxy-3,4'-dimethoxyflavone
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-
Kaempferol-3,4'-dimethylether
kaempferol 3,4'-dimethyl ether
3,4'-dimethoxykaempferol
5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4-benzopyrone

Biological Activity

[Description]:

Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

COX-2

iNOS

Bacterial

[References]

[1]. Sandeep Appunni, et al. Targeting PknB, an Eukaryotic-Like serine/threonine Protein Kinase of Mycobacterium Tuberculosis With Phytomolecules. Comput Biol Chem. 2017 Apr;67:200-204.

[2]. Jih-Jung Chen, et al. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents From the Rhizomes of Curcuma Zedoaria. Molecules. 2016 Oct 17;21(10):1385.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
552.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.289

[ Flash Point ]:
206.9±23.6 °C

[ Exact Mass ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.671

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%