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Epothilone F

Names

[ CAS No. ]:
208518-52-9

[ Name ]:
Epothilone F

[Synonym ]:
epothilone F
(1S,3S(E),7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-3-[(E)-2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Biological Activity

[Description]:

Epothilone F is a Microtubule/Tubulin-stabilizing agent with anti-tumor activity. Epothilone F inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, drug-resistant ovarian cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Flörsheimer A, et al. Epothilones and their analogues-a new class of promising microtubule inhibitors[J]. Expert Opinion on Therapeutic Patents, 2001, 11(6): 951-968.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H41NO7S

[ Molecular Weight ]:
523.68200

[ Exact Mass ]:
523.26000

[ PSA ]:
157.72000

[ LogP ]:
3.66140

Related Compounds