Saikosaponin C

Names

[ CAS No. ]:
20736-08-7

[ Name ]:
Saikosaponin C

[Synonym ]:
Saikosaponin c standard
(3β,16β)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-α-L-altropyranosyl-(1->4)-[β-D-glucopyranosyl-(1->6)]-β-D-glucopyranoside
SaikosaponinC
β-D-glucopyranoside, (3β,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl O-6-deoxy-α-L-altropyranosyl-(1->4)-O-[β-D-glucopyranosyl-(1->6)]-
Saikosaponin C
SAIKOSAPONIN A(P)
Saikosaponian C
β-D-Glucopyranoside, (3β,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl O-6-deoxy-β-L-altropyranosyl-(1->4)-O-[β-D-glucopyranosyl-(1->6)]-
chikusakoside II
SAIKOSAPONIN C(P)
(3β,16β)-16,23-Dihydroxy-13,28-epoxyolean-11-en-3-yl 6-deoxy-β-L-altropyranosyl-(1->4)-[β-D-glucopyranosyl-(1->6)]-β-D-glucopyranoside

Biological Activity

[Description]:

Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Lee TH1, et al. A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent. J Neurochem. 2016 Mar;136(6):1232-1245.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
310-314ºC

[ Molecular Formula ]:
C₄₈H₇₈O₁₈

[ Molecular Weight ]:
943.122

[ Exact Mass ]:
942.518799

[ PSA ]:
287.14000

[ LogP ]:
2.35

[ Index of Refraction ]:
1.632

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26

Related Compounds

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