BU 224 hydrochloride
Names
[ CAS No. ]:
205437-64-5
[ Name ]:
BU 224 hydrochloride
Biological Activity
[Description]:
BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].
[Related Catalog]:
[Target]
TNF-α
[In Vivo]
BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice[1]. BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1]. BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity[2]. Animal Model: 5XFAD mice and and WT littermates (6-month-old)[1] Dosage: 0 mg/kg, 5 mg/kg Administration: IP, twice a day for 10 days Result: Significantly increased immobility (54% increased freezing), and reversed memory deficits secondary to the deposition of Aβ in the brain.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C12H12ClN3
[ Molecular Weight ]:
233.69700
[ Exact Mass ]:
233.07200
[ PSA ]:
37.28000
[ LogP ]:
2.15100
Related Compounds
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