Glycolithocholic Acid-d4 MaxSpec® Standard

Names

[ CAS No. ]:
2044276-16-4

[ Name ]:
Glycolithocholic Acid-d4 MaxSpec® Standard

[Synonym ]:
MFCD06658889
Glycine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-
N-[(3α,5β)-3-Hydroxy-24-oxo(2,2,4,4-2H4)cholan-24-yl]glycine
Glycolithocholic Acid-d4

Biological Activity

[Description]:

Glycolithocholic acid-d4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vitro]

Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

[References]

[1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91.

[2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629.

[3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405.

[4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
619.7±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₉D₄NO₄

[ Molecular Weight ]:
437.649

[ Flash Point ]:
328.6±24.6 °C

[ Exact Mass ]:
437.344330

[ LogP ]:
5.58

[ Vapour Pressure ]:
0.0±4.1 mmHg at 25°C

[ Index of Refraction ]:
1.533

Related Compounds

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