Luteollin 5-glucoside

Names

[ CAS No. ]:
20344-46-1

[ Name ]:
Luteollin 5-glucoside

[Synonym ]:
Luteolin-5-O-b-D-glucopyranoside
2-(3,4-Dihydroxyphenyl)-5-(b-D-glucopyranosyloxy)-7-hydroxy-4H-1-benzopyran-4-one
Luteolin-5-O-glucopyranoside
2-(3,4-Dihydroxyphenyl)-7-hydroxy-4-oxo-4H-chromen-5-yl β-D-glucopyranoside
Luteolin-5-O-β-D-glucopyranoside
Luteollin 5-glucoside
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-(β-D-glucopyranosyloxy)-7-hydroxy-
galuteolin
luteolin 5-O-β-D-glucopyranosyl

Biological Activity

[Description]:

Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[In Vitro]

Luteolin 5-O-glucoside, at a non-toxic concentration, inhibits LPS-induced NO production and t-BHP-induced ROS generation in a dose-dependent manner in RAW 264.7 cells. Luteolin 5-O-glucoside also suppresses the expression of iNOS and COX-2 in LPS-stimulated macrophages[1].

[References]

[1]. Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside.Food Chem Toxicol. 2012 Jun;50(6):2171-9.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
864.2±65.0 °C at 760 mmHg

[ Melting Point ]:
260-263℃

[ Molecular Formula ]:
C₂₁H₂₀O₁₁

[ Molecular Weight ]:
448.377

[ Flash Point ]:
305.8±27.8 °C

[ Exact Mass ]:
448.100555

[ PSA ]:
190.28000

[ LogP ]:
0.13

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.740

Safety Information

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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