MAO-B-IN-15

Names

[ CAS No. ]:
2032436-79-4

[ Name ]:
MAO-B-IN-15

Biological Activity

[Description]:

MAO-B-IN-15 is a selective MAO-B inhibitor (IC50: 13.5 μM) that forms π-π interaction with Tyr 326 residue. MAO-B-IN-15 can be used in the research of Parkinson’s disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

hMAO-B:13.5 μM (IC50)

hMAO-A:>100 μM (IC50)


[In Vitro]

MAO-B-IN-15 (Compound 4i, 0.01-1000 μM, 1 h) dose-dependently inhibits MAO-B activity[1]. MAO-B-IN-15 (10 μM, 24 h) has no effect on cell viability of SH-SY5Y cells[1].

[References]

[1]. Makito Yamada, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. https://doi.org/10.1021/acsmedchemlett.2c00228.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18FNO2

[ Molecular Weight ]:
287.33

Related Compounds