7-METHYLGUANOSINE

Names

[ CAS No. ]:
20244-86-4

[ Name ]:
7-METHYLGUANOSINE

[Synonym ]:
7-methlguanosine
N7-Methylguanosin
7-Methylguanosinium-Kation
7-Methylguanosine
2-amino-6,9-dihydro-7-methyl-6-oxo-9-1H-Purinium
7-methyl-guanosine

Biological Activity

[Description]:

7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 µM.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26(1):191-199.

Chemical & Physical Properties

[ Melting Point ]:
165ºC

[ Molecular Formula ]:
C₁₁H₁₆N₅O₅+

[ Molecular Weight ]:
298.27500

[ Exact Mass ]:
298.11500

[ PSA ]:
150.50000

[ Index of Refraction ]:
1.86

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.

J. Chromatogr. A. 1365 , 12-8, (2014)

A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer b...

Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity.

PLoS Genet. 11 , e1005586, (2015)

tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their pre...

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.

Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009)

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to ca...