Vilanterol-d4 (triphenylacetate)

Names

[ CAS No. ]:
2021249-10-3

[ Name ]:
Vilanterol-d4 (triphenylacetate)

[Synonym ]:
Triphenylacetic acid - 4-[(1R)-2-{[6-({2-[(2,6-dichlorobenzyl)oxy](2H4)ethyl}oxy)hexyl]amino}-1-hydroxyethyl]-2-(hydroxymethyl)phenol (1:1)
Benzeneacetic acid, α,α-diphenyl-, compd. with (α1R)-α1-[[[6-[[2-[(2,6-dichlorophenyl)methoxy]ethyl-1,1,2,2-d4]oxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol (1:1)
Vilanterol-d4 (triphenylacetate)

Biological Activity

[Description]:

Vilanterol-d4 (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Slack RJ, et al. In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013 Jan;344(1):218-30

[3]. Kempsford R, et al. Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013 Apr;26(2):256-

[4]. Harrell AW, et al. Metabolism and disposition of Vilanterol, a long-acting β(2)-adrenoceptor agonist for inhalation use in humans. Drug Metab Dispos. 2013 Jan;41(1):89-100.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₄₅D₄Cl₂NO₇

[ Molecular Weight ]:
778.79

[ Exact Mass ]:
777.313721

Related Compounds

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