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(Z)-JIB-04

Names

[ CAS No. ]:
199596-24-2

[ Name ]:
(Z)-JIB-04

[Synonym ]:
Methanone, phenyl-2-pyridinyl-, 2-(5-chloro-2-pyridinyl)hydrazone, (Z)-
5-Chloro-2-{(2Z)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine
Z-JIB-04
NSC 693627
JIB-04 (NSC 693627)-Z

Biological Activity

[Description]:

(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes [1].

[References]

[1]. Wang L, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
472.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H13ClN4

[ Molecular Weight ]:
308.765

[ Flash Point ]:
239.8±31.5 °C

[ Exact Mass ]:
308.082886

[ LogP ]:
3.92

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
-20℃

Related Compounds