NNC 26-9100

Names

[ CAS No. ]:
199522-35-5

[ Name ]:
NNC 26-9100

[Synonym ]:
Pam3CSK4 Biotin

Biological Activity

[Description]:

NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Neurological Disease

[References]

[1]. Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.

[2]. Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.

Chemical & Physical Properties

[ Density]:
1.482g/cm3

[ Boiling Point ]:
731.167ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₅BrCl₂N₆S

[ Molecular Weight ]:
556.35

[ Flash Point ]:
395.996ºC

[ Exact Mass ]:
554.04200

[ PSA ]:
100.96000

[ LogP ]:
6.14940

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.668

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.