(±)-LY367385

Names

[ CAS No. ]:
198419-90-8

[ Name ]:
(±)-LY367385

Biological Activity

[Description]:

(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vivo]

mGluR1a拮抗剂

[References]

[1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.

[2]. V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. europharmacology. 1999 Feb;38(2):199-207.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₁NO₄

[ Molecular Weight ]:
209.19900

[ Exact Mass ]:
209.06900

[ PSA ]:
100.62000

[ LogP ]:
1.47790

Related Compounds

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