ZEN-3219

Names

[ CAS No. ]:
1952264-34-4

[ Name ]:
ZEN-3219

Biological Activity

[Description]:

ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4 (BD1):0.48 μM (IC50)

BRD4 (BD2):0.16 μM (IC50)

BRD4(BD1BD2):0.47 μM (IC50)

[References]

[1]. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈N₂O₃

[ Molecular Weight ]:
322.36

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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