mPGES1-IN-16

Names

[ CAS No. ]:
1915003-93-8

[ Name ]:
mPGES1-IN-16

Biological Activity

[Description]:

mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.

[References]

References 1. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. View Related Products by Target PGE synthase

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₅N₃O₃

[ Molecular Weight ]:
485.628

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.