L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-
Names
[ CAS No. ]:
18921-68-1
[ Name ]:
L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-
[Synonym ]:
Deazaminopterin
Deaza-Aminopterin
Dideaza-aminopterin
N-{4-[(2,4-diamino-quinazolin-6-ylmethyl)-amino]-benzoyl}-glutamic acid
N-[4-[[(2,4-Diaminoquinazolin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
CB-3702
5,8-Dideazaaminopterin
Chemical & Physical Properties
[ Density]:
1.508g/cm3
[ Molecular Formula ]:
C21H22N6O5
[ Molecular Weight ]:
438.43700
[ Exact Mass ]:
438.16500
[ PSA ]:
193.55000
[ LogP ]:
3.08040
[ Index of Refraction ]:
1.747
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MA1247500
- CHEMICAL NAME :
- Glutamic acid, N-(p-(((2,4-diamino-6-quinazolinyl)methyl)amino)benzo yl)-, L-
- CAS REGISTRY NUMBER :
- 18921-68-1
- LAST UPDATED :
- 198312
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H22-N6-O5
- MOLECULAR WEIGHT :
- 438.49
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506
Safety Information
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%