Cl-4AS-1
Names
[ CAS No. ]:
188589-66-4
[ Name ]:
Cl-4AS-1
Biological Activity
[Description]:
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].
[Related Catalog]:
[Target]
IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]
[In Vitro]
Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1]. Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].
[In Vivo]
Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1]. Animal Model: ORX rats[1] Dosage: 10 mg/kg Administration: I.s.; 7 days Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H33ClN2O2
[ Molecular Weight ]:
441.01
[ Exact Mass ]:
440.22300
[ PSA ]:
49.41000
[ LogP ]:
5.54500