JK-273

Names

[ Name ]:
JK-273

[Synonym ]:
6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(4-aminophenyl)-N-(3-chlorophenyl)-

Biological Activity

[Description]:

A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.

[References]

References 1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360. View Related Products by Target Integrin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₄ClN₅

[ Molecular Weight ]:
335.790

[ Exact Mass ]:
335.093781

[ LogP ]:
4.70

[ Index of Refraction ]:
1.777

Related Compounds

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