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iCRT-5

Names

[ CAS No. ]:
18623-44-4

[ Name ]:
iCRT-5

Biological Activity

[Description]:

iCRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block Wnt/β-catenin reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma[1][2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

β-catenin-regulated transcription (CRT)[1]


[References]

[1]. Käfer R, et, al. Inhibitors of β-catenin affect the immuno-phenotype and functions of dendritic cells in an inhibitor-specific manner. Int Immunopharmacol. 2016 Mar;32:118-124.

[2]. Narayanan BA, et, al. Antagonistic effect of small-molecule inhibitors of Wnt/β-catenin in multiple myeloma. Anticancer Res. 2012 Nov;32(11):4697-707.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H17NO5S2

[ Molecular Weight ]:
367.44000

[ Exact Mass ]:
367.05500

[ PSA ]:
133.46000

[ LogP ]:
2.70770

Related Compounds