Serotonin hydrogen maleate

Names

[ Name ]:
Serotonin hydrogen maleate

[Synonym ]:
5-HYDROXYTRYPTAMINE MALEATE SALT
MFCD00043256
EINECS 242-399-6
3-(2-Aminoethyl)-5-hydroxyindole hydrogen maleate,5-HT,5-Hydroxytryptamine hydrogen maleate

Chemical & Physical Properties

[ Boiling Point ]:
416.1ºC at 760mmHg

[ Melting Point ]:
154-158ºC (dec.)

[ Molecular Formula ]:
C₁₄H₁₆N₂O₅

[ Molecular Weight ]:
292.28700

[ Flash Point ]:
205.4ºC

[ Exact Mass ]:
292.10600

[ PSA ]:
136.64000

[ LogP ]:
1.78680

[ Vapour Pressure ]:
1.63E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2560000

CHEMICAL NAME :: Indol-5-ol, 3-(2-aminoethyl)-, maleate

CAS REGISTRY NUMBER :: 18525-25-2

LAST UPDATED :: 198212

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N2-O.C4-H4-O4

MOLECULAR WEIGHT :: 292.32

WISWESSER LINE NOTATION :: T56 BMJ D2Z GQ &QV1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 33,282,1970

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NM2560000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.

Neurobiol. Learn. Mem. 116 , 162-71, (2014)

Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate tha...

Permeation of Dopamine Sulfate through the Blood-Brain Barrier.

PLoS ONE 10 , e0133904, (2015)

Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from per...

Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease.

J. Biol. Inorg. Chem. 19(8) , 1355-65, (2014)

Serotonin (5-HT) is an essential neurotransmitter for cognitive functions and formation of new memories. A deficit in 5-HT dependent neuronal activity is somewhat specific for Alzheimer's disease. Met...