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Cofrogliptin (HSK7653)(compound 2)

Names

[ CAS No. ]:
1844874-26-5

[ Name ]:
Cofrogliptin (HSK7653)(compound 2)

[Synonym ]:
Cofrogliptin (HSK7653) (compound 2)

Biological Activity

[Description]:

Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Research Areas >> Metabolic Disease

[Target]

IC50: 4.18 nM (DPP-4) [2]


[In Vitro]

Cofrogliptin (HSK7653) (compound 2) has the DPP-4 inhibitory activity with an IC50 value of 4.18 nM[2].

[References]

[1]. International Nonproprietary Names for Pharmaceutical Substances (INN)

[2]. Chen Zhang, et al. Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. J Med Chem. 2020 Jul 9;63(13):7108-7126.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19F5N4O3S

[ Molecular Weight ]:
466.43

Related Compounds