NBI 27914 hydrochloride

Names

[ Name ]:
NBI 27914 hydrochloride

[Synonym ]:
Lopac-N-3911
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine
Tocris-1591
NBI 27914 hydrochloride

Biological Activity

[Description]:

NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> CRFR

[References]

[1]. Liaw CW, et al. Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors. Mol Endocrinol. 1997;11(13):2048-2053.

Chemical & Physical Properties

[ Density]:
1.417g/cm3

[ Boiling Point ]:
483.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₁Cl₅N₄

[ Molecular Weight ]:
470.65100

[ Flash Point ]:
246.3ºC

[ Exact Mass ]:
468.02100

[ PSA ]:
41.05000

[ LogP ]:
7.64360

[ Appearance of Characters ]:
solid white

[ Vapour Pressure ]:
1.64E-09mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 16 mg/mL at 60 °C, soluble

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds

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