PTIO

Names

[ Name ]:
PTIO

[Synonym ]:
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide
2-phenyl-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl
2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL
1H-Imidazol-1-yloxy, 4,5-dihydro-4,4,5,5-tetramethyl-3-oxido-2-phenyl-
4,5-Dihydro-4,4,5,5-tetramethyl-3-oxido-2-phenyl-1H-Imidazol-1-yloxy
2-phenyl-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazolyl-1-oxy 3-oxide radical
2-phenyl-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazolyl-1-oxyl-3-N-oxide
2-phenyl-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl 3-oxide
4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-2-PHENYL-1H-IMIDAZOL-1-YLOXY-1-OXIDE
PTIO
2-Phenyl-4,4,5,5-tetramethylimidazoline 3-oxide 1-oxyl
2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide
4,4,5,5-tetramethyl-2-phenyl-4,5-dihydro-1H-imidazole-1-oxyl 3-oxide
(4,4,5,5-Tetramethyl-3-oxido-2-phenyl-4,5-dihydro-1H-imidazol-1-yl)oxidanyl
2-phenyl-4,4,5,5-tetramethyl-2,5-dihydro-1H-imidazol-1-oxyl 3-N-oxide
(2-Phenyl-4,4,5,5-tetraMethyliMidazoline-3-oxide-1-oxyl)
4,4,5,5-tetramethyl-2-phenyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl

Biological Activity

[Description]:

PTIO is a specific scavenger of NO. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Xia JL , et al. Putrescine regulates nitric oxide accumulation in Ganoderma lucidum partly by influencing cellular glutamine levels under heat stress. Microbiol Res. 2020;239:126521.

[2]. Goldstein S, et al. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*. J Biol Chem. 2003;278(51):50949-50955.

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
359.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₇N₂O₂

[ Molecular Weight ]:
233.286

[ Flash Point ]:
171.3ºC

[ Exact Mass ]:
233.128998

[ PSA ]:
31.99000

[ LogP ]:
2.05850

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Nitric oxide induces cancer stem cell-like phenotypes in human lung cancer cells.

Am. J. Physiol. Cell Physiol. 308(2) , C89-100, (2015)

Even though tremendous advances have been made in the treatment of cancers during the past decades, the success rate among patients with cancer is still dismal, largely because of problems associated ...

Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke.

J. Neurosci. 34(40) , 13535-48, (2014)

Stroke is a major public health concern. The lack of effective therapies heightens the need for new therapeutic targets. Mammalian brain has the ability to rewire itself to restore lost functionalitie...

Cardiac contractility in Antarctic teleost is modulated by nitrite through xanthine oxidase and cytochrome p-450 nitrite reductase.

Nitric Oxide 49 , 1-7, (2015)

In mammalian and non-mammalian vertebrates, nitrite anion, the largest pool of intravascular and tissue nitric oxide storage, represents a key player of many biological processes, including cardiac mo...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.